Beings who possess animal-like powers walk among humans in this alternate universe. These mysterious mutants--the +Anima--are shunned by society... Four outcasts in particular--Cooro, a boy with crow-like powers; Husky
, a fish-boy; Senri
, a bear +Anima; and a girl named Nana
, who wields bat powers--search for others like themselves while trying to gain acceptance in a world cruel to anyone or anything that is different.
is a +Anima: a person with animal characteristics. The +Anima dwell amongst ordinary humans but are ostracized, hated, and enslaved. Cooro
, brought up as an orphan, goes on a quest to find more +Anima and to gain acceptance in a world that is fearful of anything different. With Husky
at his side, Cooro
sets off on a trip around the world, having adventures, making friends, and searching for his own identity. But as they become more entangled in various plots and the churning backgrounds of each +Anima, will they be able to maintain their friendship, as well as their safety?