Edo, 1855, in the Hill of the Three Hundred district: Japan's isolationist foreign policy has been lifted, and the era of the Bakumatsu has begun. The samurai Ibuya Manjiro, 26 years old, has just begun his career as low-ranking retainer to the minor daimyo Lord Matsudaira. Tezuka Ryoan, 29, a disciple of Dutch medicine, has just been accepted as a student at Teki Academy in Osaka. Each has a temper to go with his talent, and in a time of brewing upheaval the two are not slow to find trouble, which brings them together in spite of their mutual dislike. Tezuka is called in one night to sew up Ibuya after an illicit duel; a few weeks later, Ibuya finds himself the only thing standing between Tezuka and a gang of swordsmen sent by the head of medicine for the Shogunate.

Note: Won the Shogakukan Manga Award for general manga in 1984.