Fullmetal Alchemist: Brotherhood

The Elrics are not alone in their search; the corrupt State Military is eager to harness the artifact’s power. So too are the strange Homunculi and their shadowy creator. The mythical gem lures exotic alchemists from distant kingdoms, scarring some deeply enough to inspire murder. As the Elrics find their course altered by these enemies and allies, their purpose remains unchanged – and their bond unbreakable.

In this world there exist alchemists, people who study and perform the art of alchemical transmutation—to manipulate objects and transform one object into another. They are bounded by the basic law of alchemy: in order to gain something you have to sacrifice something of the same value.
The main character is the famous alchemist Edward Elric—also known as the Fullmetal Alchemist—who almost lost his little brother, Alphonse, in an alchemical accident. Edward managed to attach his brother’s soul to a large suit of armor. While he did manage to save his brother’s life, he paid the terrible price of his limbs.
To get back what they’ve lost, the brothers embark on a journey to find the Philosopher’s Stone that is said to amplify the powers of an alchemist enormously. However on the way, they start uncovering a conspiracy that could endanger the entire nation, and they realize the misfortunes brought upon by the Philosopher’s Stone.
Fullmetal Alchemist: Brotherhood is a re-telling of the story from the manga point of view.

The foundation of alchemy is based on the law of equivalent exchange; you cannot produce something from nothing. As such, alchemy is bound by one taboo – human transmutation. Four years ago two young brothers, Edward and Alphonse Elric, broke this taboo when they tried to resurrect their dead mother. During the process Al’s body disintegrated and Ed lost his leg. In a desperate attempt to prevent his brother from disappearing completely, Ed sacrificed one of his arms so he could affix Al’s soul to a suit of armor. When his missing limbs are replaced by auto mail parts, Ed bears the name of the Fullmetal Alchemist – the youngest ever State Alchemist and dog of the military. Now, alongside his brother, Ed uses his status within the military to attempt to find any way that he can return their bodies back to their original state.