Saikano

Shuji and Chise are high school seniors in a small town who have just started dating when Shuji discovers that Chise has been engineered by the SDF so that she can transform herself into a powerful weapon. While Shuji and Chise keep trying to nurture their relationship, Chise continues to grow even more powerful as the Ultimate Weapon, and becomes increasingly torn between being a destructive fighting force and remaining an ordinary teenager. What do you do when the girl you love becomes a weapon of mass destruction?

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Shuuji and Chise are third year students at a high school in Hokkaido. The shy Chise is finally confessing to Shuuji, and finally the two of them are starting to exchange diary awkwardly. One day, Shuuji tries to escape from a sudden enemy air raid on Sapporo. While desperately escaping from the air raid, Shuuji sees a scene that he could not forget for his life. He sees Chise, with a huge weapon looking as if it was part of her hand, shooting the enemy fighters down one by one. Apparently, Chise is the ultimate weapon with destructive power which is important for the war.

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In the not-so-distant future, mankind is at war with itself. The lives of Chise and Shuu are torn apart when Chise is chosen to become the ultimate weapon to fight for Japan against their enemies. Death, sadness, and the hardships of love accompany Sai Kano in its grim look at war and its consequences.